Researchers have shown that deforestation can drive outbreaks by bringing people closer to wildlife, which can shed dangerous viruses. Scientists found these dynamics can explain several recent outbreaks of Ebola, including the largest one nearly a decade ago in Guinea, which scientists believe started after a toddler played in a tree that was home to a large colony of bats.

But this Portland, Oregon-based nonprofit, with an annual budget of just $5.3 million for programs in three countries, is demonstrating how working creatively across health, agriculture and the environment may be the key to prevention.

The organization has managed to quantify its success at its pilot location in a rural part of Indonesia on the island of Borneo. With help from Stanford University researchers, Health In Harmony analyzed 10 years of patient records along with satellite images of the forest there, comparing 73 villages that signed its agreement to places that hadn’t. They estimated that the project averted 10.6 square miles of deforestation and achieved significant declines in malaria, tuberculosis, neglected tropical illnesses and chronic obstructive pulmonary diseases, even while the rates for some of these conditions increased in the surrounding region.

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